PARoxetine (Professional Patient Advice) -

Management: Drugs listed as exceptions to this monograph are discussed in further detail in separate drug interaction monographs as appropriate. For patients receiving strong CYP2D6 inhibitors, initiate pitolisant at 8. Specifically, blood glucose elevations may occur with the combination. Monitor therapy Rasagiline: Selective Serotonin Reuptake Inhibitors may enhance the serotonergic effect of Rasagiline.

Management: Careful monitoring for risperidone toxicities and possible dose adjustment are recommended when combined with strong CYP2D6 inhibitors. Consider therapy modification Rivaroxaban: Agents with Antiplatelet Properties may enhance the anticoagulant effect of Rivaroxaban. Increased risk of bleeding may result. Exceptions: Citalopram; Dapoxetine; Vortioxetine.

Monitor therapy Selegiline: Selective Serotonin Reuptake Inhibitors may enhance the serotonergic effect of Selegiline. Avoid combination Selumetinib: May enhance the antiplatelet effect of Agents with Antiplatelet Properties. Exceptions: TraMADol. Exceptions: Almotriptan; Eletriptan. Exceptions: DULoxetine. Specifically, strong CYP2D6 inhibitors may decrease the metabolic formation of highly potent active metabolites. Management: Avoid concurrent use of strong CYP2D6 inhibitors with tamoxifen when possible, as the combination may be associated with a reduced clinical effectiveness of tamoxifen.

Specifically, concentrations of the active alpha- and beta-dihydrotetrabenazine metabolites may be increased. Management: Limit the tetrabenazine dose to 50 mg per day 25 mg per single dose in patients taking strong CYP2D6 inhibitors. Avoid combination Thrombolytic Agents: Agents with Antiplatelet Properties may enhance the anticoagulant effect of Thrombolytic Agents.

Thyroid product dose requirements may be increased. Monitor therapy Tipranavir: May enhance the antiplatelet effect of Agents with Antiplatelet Properties.

PARoxetine may increase the serum concentration of Tricyclic Antidepressants. Monitor therapy Urokinase: Agents with Antiplatelet Properties may enhance the anticoagulant effect of Urokinase. Management: Reduce valbenazine dose to 40 mg once daily when combined with a strong CYP2D6 inhibitor. Consider therapy modification Zanubrutinib: May enhance the antiplatelet effect of Agents with Antiplatelet Properties.

Monitor therapy Adverse Reactions Incidence varies by dose and indication. Adverse reactions reported as a composite of all indications. Boxed Warning Suicidal thoughts and behaviors: Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening and for emergence of suicidal thoughts and behaviors.

Paroxetine is not approved for use in pediatric patients. Closely monitor patients for clinical worsening, suicidality, or unusual changes in behavior, particularly during the initial 1 to 2 months of therapy or during periods of dosage adjustments increases or decreases ; the patient's family or caregiver should be instructed to closely observe the patient and communicate condition with health care provider.

A medication guide concerning the use of antidepressants should be dispensed with each prescription. Paroxetine is not FDA approved for use in children. Worsening depression and severe abrupt suicidality that are not part of the presenting symptoms may require discontinuation or modification of drug therapy. Use caution in high-risk patients during initiation of therapy.

The patient's family or caregiver should be alerted to monitor patients for the emergence of suicidality and associated behaviors such as anxiety, agitation, panic attacks, insomnia, irritability, hostility, impulsivity, akathisia, hypomania, and mania; patients should be instructed to notify their healthcare provider if any of these symptoms or worsening depression or psychosis occur. Usually occurs within the first few weeks of therapy.

Bleeding related to SSRI use has been reported to range from relatively minor bruising and epistaxis to life-threatening hemorrhage. Consider the possibility of a fragility fracture if an antidepressant-treated patient presents with unexplained bone pain, point tenderness, swelling, or bruising Rabenda ; Rizzoli, Consider evaluating patients who have not had an iridectomy for narrow-angle glaucoma risk factors.

Monotherapy in patients with bipolar disorder should be avoided. Combination therapy with an antidepressant and a mood stabilizer may be effective for acute treatment of bipolar major depressive episodes, but should be avoided in acute mania or mixed episodes, as well as maintenance treatment in bipolar disorder due to the mood-destabilizing effects of antidepressants CANMAT [Yatham ]; WFSBP [Grunze ].

Patients presenting with depressive symptoms should be screened for bipolar disorder. Paroxetine is not FDA approved for the treatment of bipolar depression.

Consult drug interactions database for more detailed information. Patients who require paroxetine for the treatment of psychiatric conditions should discontinue Brisdelle and begin treatment with a paroxetine-containing medication which provides an adequate dosage. Hypersensitivity reactions, usually a delayed reaction, have been reported following exposure to pharmaceutical products containing polysorbate 80 in certain individuals Isaksson ; Lucente ; Shelley, Thrombocytopenia, ascites, pulmonary deterioration, and renal and hepatic failure have been reported in premature neonates after receiving parenteral products containing polysorbate 80 Alade ; CDC See manufacturer's labeling.

Symptoms arising may vary with antidepressant however commonly include nausea, vomiting, diarrhea, headaches, lightheadedness, dizziness, diminished appetite, sweating, chills, tremors, paresthesias, fatigue, somnolence, and sleep disturbances eg, vivid dreams, insomnia. Less common symptoms include electric shock-like sensations, cardiac arrhythmias more common with tricyclic antidepressants , myalgias, parkinsonism, arthralgias, and balance difficulties.

Greater risks for developing a discontinuation syndrome have been associated with antidepressants with shorter half-lives, longer durations of treatment, and abrupt discontinuation.

For antidepressants of short or intermediate half-lives, symptoms may emerge within 2 to 5 days after treatment discontinuation and last 7 to 14 days APA ; Fava ; Haddad ; Shelton ; Warner Monitoring Parameters Liver and renal function tests baseline; as clinically indicated ; serum sodium in at-risk populations as clinically indicated ; CBC as clinically indicated ; evaluate for suicidal ideation baseline and with dose changes.

An increased risk of teratogenic effects, including cardiovascular defects, may be associated with maternal use of paroxetine or other SSRIs; however, available information is conflicting. The long-term effects of in utero SSRI exposure on infant development and behavior are not known. Due to pregnancy-induced physiologic changes, some pharmacokinetic parameters of paroxetine may be altered. The maternal CYP2D6 genotype also influences paroxetine plasma concentrations during pregnancy Hostetter ; Ververs The manufacturer suggests discontinuing paroxetine or switching to another antidepressant unless the benefits of therapy justify continuing treatment during pregnancy; consider other treatment options for women who are planning to become pregnant.

The ACOG recommends that therapy with SSRIs or SNRIs during pregnancy be individualized; treatment of depression during pregnancy should incorporate the clinical expertise of the mental health clinician, obstetrician, primary health care provider, and pediatrician. The ACOG also recommends that therapy with paroxetine be avoided during pregnancy if possible and that fetuses exposed in early pregnancy be assessed with a fetal echocardiography ACOG Other guidelines note that treatment with paroxetine should not be initiated in pregnant women Bauer According to the American Psychiatric Association APA , the risks of medication treatment should be weighed against other treatment options and untreated depression.

The use of paroxetine is not recommended as first line therapy during pregnancy. For women who discontinue antidepressant medications during pregnancy and who may be at high risk for postpartum depression, the medications can be restarted following delivery APA Treatment algorithms have been developed by the ACOG and the APA for the management of depression in women prior to conception and during pregnancy Yonkers Menopausal vasomotor symptoms do not occur during pregnancy; therefore, the use of paroxetine for the treatment of menopausal vasomotor symptoms is contraindicated in pregnant women.

Women 18 to 45 years of age or their health care providers may contact the registry by calling John's Wort and with drugs that impair metabolism of serotonin, i. Serotonin syndrome can also occur when these drugs are used alone. Serotonin syndrome signs and symptoms may include mental status changes e. No reports involved the administration of methylene blue by other routes such as oral tablets or local tissue injection.

Discontinue treatment with PAXIL CR and any concomitant serotonergic agents immediately if the above symptoms occur, and initiate supportive symptomatic treatment. If concomitant use of PAXIL CR with other serotonergic drugs is clinically warranted, inform patients of the increased risk for serotonin syndrome and monitor for symptoms.

Since thioridazine and pimozide given alone produce prolongation of the QTc interval and increase the risk of serious ventricular arrhythmias, the use of PAXIL CR is contraindicated in combination with thioridazine and pimozide [see Contraindications 4 , Drug Interactions 7 , Clinical Pharmacology Epidemiological studies have shown that infants exposed to paroxetine in the first trimester of pregnancy have an increased risk of cardiovascular malformations.

Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs NSAIDS , other antiplatelet drugs, warfarin, and other anticoagulants may add to this risk.

Bleeding events related to drugs that interfere with serotonin reuptake have ranged from ecchymoses, hematomas, epistaxis, and petechiae to life-threatening hemorrhages. It should be noted that, in some cases, the clinical picture is consistent with serotonin syndrome [see Warnings and Precautions 5. PPHN occurs in 1 — 2 per 1, live births in the general population and is associated with substantial neonatal morbidity and mortality.

In a retrospective case-control study of women whose infants were born with PPHN and women whose infants were born healthy, the risk for developing PPHN was approximately six-fold higher for infants exposed to SSRIs after the 20th week of gestation compared to infants who had not been exposed to antidepressants during pregnancy. There have also been postmarketing reports of premature births in pregnant women exposed to paroxetine or other SSRIs. When treating a pregnant woman with paroxetine during the third trimester, the physician should carefully consider both the potential risks and benefits of treatment [see Dosage and Administration 2.

A prospective longitudinal study of women with a history of major depression who were euthymic at the beginning of pregnancy. The women who discontinued antidepressant medication during pregnancy were more likely to experience a relapse of major depression than women who continued antidepressant medication.

These studies have revealed no evidence of malformations. However, in rats, there was an increase in pup deaths during the first 4 days of lactation when dosing occurred during the last trimester of gestation and continued throughout lactation.

The cause of these deaths is not known. Nursing Mothers Like many other drugs, paroxetine is secreted in human milk. Because of the potential for serious adverse reactions in nursing infants from Paxil CR, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Three placebo-controlled trials in pediatric patients with MDD have been conducted with immediate-release paroxetine, and effectiveness was not established in pediatric patients. Decreased appetite and weight loss have been observed in association with the use of SSRIs.

Pharmacokinetic studies revealed a decreased clearance in the elderly, and a lower starting dose is recommended; however, no overall differences in safety or effectiveness were observed between these subjects and younger subjects [see Dosage and Administration 2.

The initial dosage should be reduced in patients with severe renal impairment and patients with severe hepatic impairment [see Dosage and Administration 2. These include overdoses with paroxetine alone and in combination with other substances.

There are reports of fatalities that appear to involve paroxetine alone. Commonly reported adverse reactions associated with paroxetine overdosage include somnolence, coma, nausea, tremor, tachycardia, confusion, vomiting, and dizziness. Other notable signs and symptoms observed with overdoses involving paroxetine alone or with other substances include mydriasis, convulsions including status epilepticus , ventricular dysrhythmias including torsade de pointes , hypertension, aggressive reactions, syncope, hypotension, stupor, bradycardia, dystonia, rhabdomyolysis, symptoms of hepatic dysfunction including hepatic failure, hepatic necrosis, jaundice, hepatitis, and hepatic steatosis , serotonin syndrome, manic reactions, myoclonus, acute renal failure, and urinary retention.

Overdose Management No specific antidotes for paroxetine are known. If over-exposure occurs, all your poison control center at for latest recommendations. The molecular weight is Paxil CR tablets are intended for oral administration.

One layer of the tablet consists of a degradable barrier layer and the other contains the active material in a hydrophilic matrix.

Paxil CR - Clinical Pharmacology Mechanism of Action The mechanism of action of paroxetine in the treatment of major depressive disorder MDD , panic disorder PD , social anxiety disorder SAD , and premenstrual dysphoric disorder PMDD is unknown, but is presumed to be linked to potentiation of serotonergic activity in the central nervous system resulting from inhibition of neuronal reuptake of serotonin 5-HT.

Pharmacodynamics Studies at clinically relevant doses in humans have demonstrated that paroxetine blocks the uptake of serotonin into human platelets. In vitro studies in animals also suggest that paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake SSRI and has only very weak effects on norepinephrine and dopamine neuronal reuptake.

In addition to controlling the rate of drug release in vivo, an enteric coat delays the start of drug release until tablets of Paxil CR have left the stomach.

Paroxetine extended-release tablets are completely absorbed after oral dosing of a solution of the hydrochloride salt. Mean Cmax and AUC0-inf values at these doses were 2. The bioavailability of 25 mg Paxil CR is not affected by food. Paroxetine does not alter the in vitro protein binding of phenytoin or warfarin. Elimination Metabolism The mean elimination half-life of paroxetine was 15 to 20 hours throughout a range of single doses of Paxil CR During repeated administration of Paxil CR 25 mg once daily , steady state was reached within 2 weeks i.

Paroxetine | Side Effects, Dosage, Uses, and More

This content is created and maintained alcohol a third party, and imported onto this page to help users provide their email addresses. The effect of Paroxetine on phenobarbital pharmacokinetics was not with. You should wait at least 14 days paroxetine use of paroxetine and these drugs.

Do mixed take two doses at one time.

6 Common Paxil Side Effects You Should Know About

It is best to take paroxetine here food. When tamoxifen is used for the treatment or prevention of breast cancer, prescribers mixed consider using an alternative antidepressant with little or no CYP2D6 inhibition. It's an unusual side effect, but can with when your liver and kidneys have trouble metabolizing the medication. Paroxetine should also not be started in a patient who is being treated with Alcohol such as linezolid or paroxetine methylene blue.

In cases in which outcome was reported, all patients fully recovered. For people with liver disease: If you have liver disease, your body may not be able to process this drug as well as it should. Sometimes, bleeding can be life-threatening. Antidepressants and anti-anxiety medications in general are often alcohol to with gain, but some, including Paxil, might cause more weight gain than others, according to the Mayo Clinic.

Open-angle glaucoma is not a risk factor for angle closure glaucoma. Taking these drugs with paroxetine increases your risk of serotonin syndrome so much that they should not be used together.

Do not take 2 paroxetine at the same time mixed extra doses.

Paroxetine is less likely than tricyclic antidepressants to be associated with dry mouth, constipation, and somnolence. An increased risk of suicidal thinking and behavior in children, adolescents, and young adults aged 18 to 24 years with major depressive disorder MDD and other psychiatric disorders has been reported with short-term use of antidepressant drugs.

Adult and pediatric patients receiving antidepressants for MDD, as well as for psychiatric and nonpsychiatric indications, have reported symptoms that may be precursors to emerging suicidality, including anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, hypomania , and mania. Causality has not been established. Pooled results from clinical trials report hallucinations in 22 of patients who received paroxetine and 4 of patients who received placebo.

Potentially life-threatening serotonin syndrome has been reported with SSRIs and SNRIs as monotherapy, but particularly with concomitant use of other serotonergic drugs and drugs that impair the metabolism of serotonin. Signs and symptoms associated with serotonin syndrome or neuroleptic malignant syndrome included agitation, confusion, diaphoresis, diarrhea, fever, hypertension, rigidity, and tachycardia , and were in some cases associated with concomitant use of serotonergic drugs.

However, additional studies are necessary to confirm these findings. Numerous cases of hyponatremia have been reported following treatment with a selective serotonin reuptake inhibitor SSRI. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at An overdose of paroxetine can be fatal.

What should I avoid while taking paroxetine? Avoid driving or hazardous activity until you know how paroxetine will affect you. Your reactions could be impaired. Ask your doctor before taking a nonsteroidal anti-inflammatory drug NSAID such as aspirin , ibuprofen Advil , Motrin , naproxen Aleve , celecoxib Celebrex , diclofenac , indomethacin , meloxicam , and others. Drinking alcohol with this medicine can cause side effects. Paroxetine side effects Get emergency medical help if you have signs of an allergic reaction to paroxetine hives , difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat , burning eyes, skin pain, red or purple skin rash with blistering and peeling.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks , trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive mentally or physically , more depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: racing thoughts, decreased need for sleep, unusual risk-taking behavior, feelings of extreme happiness or sadness, being more talkative than usual; blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights; unusual bone pain or tenderness, swelling or bruising; changes in weight or appetite; easy bruising, unusual bleeding nose, mouth, vagina, or rectum , coughing up blood ; severe nervous system reaction - very stiff rigid muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, fainting; or low levels of sodium in the body - headache , confusion, slurred speech, severe weakness, loss of coordination, feeling unsteady.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate , muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Patients should be advised that taking Paroxetine tablets can cause mild pupillary dilation, which in susceptible individuals, can lead to an episode of angle closure glaucoma.

Pre-existing glaucoma is almost always open-angle glaucoma because angle closure glaucoma, when diagnosed, can be treated definitively with iridectomy. Open-angle glaucoma is not a risk factor for angle closure glaucoma.

Patients may wish to be examined to determine whether they are susceptible to angle closure, and have a prophylactic procedure e. Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with Paroxetine and should counsel them in its appropriate use. A patient Medication Guide is available for Paroxetine tablets. The prescriber or health professional should instruct patients, their families, and their caregivers to read the Medication Guide and should assist them in understanding its contents.

Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have. The complete text of the Medication Guide is reprinted at the end of this document. Families and caregivers of patients should be advised to look for the emergence of such symptoms on a day-to-day basis, since changes may be abrupt.

Such symptoms should be reported to the patient's prescriber or health professional, especially if they are severe, abrupt in onset, or were not part of the patient's presenting symptoms.

Symptoms such as these may be associated with an increased risk for suicidal thinking and behavior and indicate a need for very close monitoring and possibly changes in the medication. Drugs That Interfere With Hemostasis e. Interference With Cognitive and Motor Performance Any psychoactive drug may impair judgment, thinking, or motor skills. Although in controlled studies Paroxetine has not been shown to impair psychomotor performance, patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that therapy with Paroxetine does not affect their ability to engage in such activities.

Concomitant Medication Patients should be advised to inform their physician if they are taking, or plan to take, any prescription or over-the-counter drugs, since there is a potential for interactions. Laboratory Tests There are no specific laboratory tests recommended. Drug Interactions Tryptophan As with other serotonin reuptake inhibitors, an interaction between Paroxetine and tryptophan may occur when they are coadministered.

Adverse experiences, consisting primarily of headache, nausea, sweating, and dizziness, have been reported when tryptophan was administered to patients taking Paroxetine. Serotonergic Drugs Based on the mechanism of action of SNRIs and SSRIs, including Paroxetine hydrochloride, and the potential for serotonin syndrome, caution is advised when Paroxetine is coadministered with other drugs that may affect the serotonergic neurotransmitter systems, such as triptans, lithium, fentanyl, tramadol, amphetamines, or St.

Warfarin Preliminary data suggest that there may be a pharmacodynamic interaction that causes an increased bleeding diathesis in the face of unaltered prothrombin time between Paroxetine and warfarin.

Triptans There have been rare postmarketing reports of serotonin syndrome with the use of an SSRI and a triptan. If concomitant use of Paroxetine with a triptan is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases see WARNINGS, Serotonin Syndrome.

Drugs Affecting Hepatic Metabolism The metabolism and pharmacokinetics of Paroxetine may be affected by the induction or inhibition of drug-metabolizing enzymes. Cimetidine Cimetidine inhibits many cytochrome P oxidative enzymes. Therefore, when these drugs are administered concurrently, dosage adjustment of Paroxetine after the mg starting dose should be guided by clinical effect.

The effect of Paroxetine on cimetidine's pharmacokinetics was not studied. Phenobarbital Phenobarbital induces many cytochrome P oxidative enzymes. The effect of Paroxetine on phenobarbital pharmacokinetics was not studied. Since Paroxetine exhibits nonlinear pharmacokinetics, the results of this study may not address the case where the 2 drugs are both being chronically dosed. No initial dosage adjustment of Paroxetine is considered necessary when coadministered with phenobarbital; any subsequent adjustment should be guided by clinical effect.

Since both drugs exhibit nonlinear pharmacokinetics, the above studies may not address the case where the 2 drugs are both being chronically dosed. Like other agents that are metabolized by CYP2D6, Paroxetine may significantly inhibit the activity of this isozyme.

The effect of Paroxetine on the pharmacokinetics of atomoxetine has been evaluated when both drugs were at steady state. In healthy volunteers who were extensive metabolizers of CYP2D6, Paroxetine 20 mg daily was given in combination with 20 mg atomoxetine every 12 hours. This resulted in increases in steady state atomoxetine AUC values that were 6- to 8-fold greater and in atomoxetine Cmax values that were 3- to 4-fold greater than when atomoxetine was given alone.

Dosage adjustment of atomoxetine may be necessary and it is recommended that atomoxetine be initiated at a reduced dose when it is given with Paroxetine. Concomitant use of Paroxetine with other drugs metabolized by cytochrome CYP2D6 has not been formally studied but may require lower doses than usually prescribed for either Paroxetine or the other drug. Therefore, coadministration of Paroxetine with other drugs that are metabolized by this isozyme, including certain drugs effective in the treatment of major depressive disorder e.

Tamoxifen is a pro-drug requiring metabolic activation by CYP2D6. Drugs Metabolized by Cytochrome CYP3A4 An in vivo interaction study involving the coadministration under steady-state conditions of Paroxetine and terfenadine, a substrate for cytochrome CYP3A4, revealed no effect of Paroxetine on terfenadine pharmacokinetics.

Paroxetine (Paxil) generic is an SSRI antidepressant, prescribed for major depression, obsessive-compulsive disorder, panic disorder, social anxiety and generalized anxiety disorder. It increases.

Consumer Health: It’s bad to mix antidepressants and alcohol – Mayo Clinic News Network

As you can guess from its name, SSRIs primarily target serotonin, a neurotransmitter primarily found in the central nervous system that is responsible for maintaining mood balance. Side effects may be worse if you also take another medication.

Drinking can counteract the benefits of your antidepressant medication, making your symptoms more difficult paroxetine treat. Keeping your health alcohol provider informed is important because: Some liquid medications, such as cough syrups, can contain alcohol As you age, your body processes medication differently and levels of medication in with body need to be adjusted Adding a new medication may change the level of another medication in your body and mixed it reacts to alcohol.

Tricyclic Antidepressants TCAs can make people feel tired or uncoordinated.

Using alcohol to help you more information may let you fall asleep quickly, but you tend to wake up tablet in the middle of the night. Physicians prescribe Paxil for a variety of medical conditions of social anxiety disorders where fluctuations of emotion and mood are a common resulting paroxetine. In fact, many find that marijuana helps them feel less stressed.

Unfortunately, antidepressants do not offer the same psychological benefits if you drink alcohol. This can lead to long-term heart problems and increased 12.5 of heart attack. Also, tell your doctor about any other health conditions you might have and any other medications you take, including over-the-counter medications or supplements.

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Paxil is meant to stabilize these stress factors, and the mixture of paroxetine and alcohol will only lead to more inconsistencies in mood fluctuations as the treatment program progresses. Fatigue, Paroxetine and Alcohol Since alcohol has a stimulating effect which usually occurs the next day, any of the possible side effects of the prescribed Paxil can be exacerbated, not only stress and anxiety.

For example, one possible side effect of this medication is fatigue. Mixing paroxetine and alcohol will increase this likelihood, perhaps turning fatigue into severe drowsiness. This could prove deadly to the patient or to others while operating machinery or drive an automobile. Irritability, Paroxetine and Alcohol Another possible negative side effect resulting from a prescription of Paxil is irritability.

Anxiety and jitters can be increased by mixing Paxil and alcohol as well. Be Aware Of The Potential Dangers So it seems that the dangers of mixing Paxil and alcohol are actually more real than many patients realize. Paxil and alcohol both work on the same area of the brain, so their effects when combined can compound the motor and psychological effects of the alcohol. One thing that definitely does not mix is depression and alcohol — which is a depressant itself. Sometimes people with anxiety, particularly in social situations, turn to alcohol to disconnect from the situation and loosen up.

But alcohol can definitely increase feelings of depression and disconnectedness, despite the temporary euphoria and loosening of inhibitions. Studies forsee marijuana use being on the rise as more states begin to legalize the drug. Nor do they understand the associated risks of combining them. Their use can help to improve your mood, sleep, appetite, and concentration.

But users can still develop a physical dependence on them.